Just stumbled upon a very good article and example of CSS to 'decrappify' MySpace web profiles. Great article, thought I'd mention it here - Mike Davidson's Blog.
I have to say, I tried this technique with a blog resdesign - here: Absolute Pitch Public Relations - and while it turned out fairly nice, I find that MySpace is crazy about cross browser compatibility, still. I had lots of problems getting my 'MySpace' project to look as nice as Mike Davidson did with his blog - but I finally realized that you can't allow HTML in the comments section, or the images and other doodads your 'friends' can put in your comments will throw your tables and design out of whack.
Took me a long time to figure this out, I'm a little embarrased... but lesson learned. So - for the most part, if you want a nice clean, contained look, you have to create new template with the default MySpace CSS, (as Mike provides in his blog at above referenced link) and then turn of the HTML Friend Comments. (or as far as I know.)
Still a learning process.....